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Is There a Renaissance of Glucocorticoids in Rheumatoid Arthritis?
Author(s) -
Kirwan JR,
Gunasekera WMA
Publication year - 2017
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt.753
Subject(s) - the renaissance , rheumatoid arthritis , medicine , adverse effect , arthritis , intensive care medicine , clinical practice , physical therapy , history , art history
The first therapeutic use of glucocorticoids was in a patient with severe rheumatoid arthritis and the symptomatic benefit was astounding. Adverse effects from increasingly large doses led to them being overshadowed, dismissed as inappropriate treatment, and ignored for 20 years – but in the last 2 decades, the accumulating evidence and clinical practice suggest there is a justified renaissance in their use as a first‐line treatment.