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Regulation of ABC transporters at the blood–brain barrier
Author(s) -
Miller DS
Publication year - 2015
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt.64
Subject(s) - atp binding cassette transporter , transporter , efflux , blood–brain barrier , xenobiotic , brain function , drug , function (biology) , pharmacology , chemistry , biology , neuroscience , microbiology and biotechnology , central nervous system , biochemistry , enzyme , gene
ATP binding cassette (ABC) transporters at the blood–brain barrier function as ATP‐driven xenobiotic efflux pumps and limit delivery of small molecule drugs to the brain. Here I review recent progress in understanding the regulation of the expression and transport activity of these transporters and comment on how this new information might aid in improving drug delivery to the brain.