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Racial/ethnic differences in drug disposition and response: Review of recently approved drugs
Author(s) -
Ramamoorthy A,
Pacanowski MA,
Bull J,
Zhang L
Publication year - 2015
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt.61
Subject(s) - ethnic group , race (biology) , disposition , drug , medicine , drug response , population , pharmacology , psychology , environmental health , biology , political science , social psychology , botany , law
Race and ethnicity can contribute to interindividual differences in drug exposure and/or response, which may alter risk–benefit in certain populations. Approximately one‐fifth of new drugs approved in the past 6 years demonstrated differences in exposure and/or response across racial/ethnic groups, translating to population‐specific prescribing recommendations in a few cases. When data from diverse populations were lacking, additional postmarketing studies were recommended. In this review we highlight several cases where race/ethnicity was central to regulatory decision‐making.