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3D bioengineered tissues: From advancements in in vitro safety to new horizons in disease modeling
Author(s) -
Hardwick RN,
Viergever C,
Chen AE,
Nguyen DG
Publication year - 2017
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt.569
Subject(s) - in vitro , human disease , computational biology , computer science , biochemical engineering , disease , medicine , biology , engineering , pathology , biochemistry
Research aimed at more fully emulating human biology in vitro has rapidly progressed in recent years with advancements in 3D tissue engineering and microphysiological systems. The initial target of such systems has been directed towards drug and chemical safety assessment, with the goal of improving sensitivity and predictive capabilities. Here we discuss recent developments of in vitro organ culture systems, and their future applications in modeling human disease.