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Role of Passive Diffusion, Transporters, and Membrane Trafficking‐Mediated Processes in Cellular Drug Transport
Author(s) -
Cocucci E,
Kim JY,
Bai Y,
Pabla N
Publication year - 2017
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt.545
Subject(s) - intracellular , transporter , drug , membrane , membrane transport , microbiology and biotechnology , membrane transport protein , chemistry , transport protein , atp binding cassette transporter , drug trafficking , biophysics , biology , membrane protein , pharmacology , biochemistry , criminology , sociology , gene
Intracellular drug accumulation is thought to be dictated by two major processes, passive diffusion through the lipid membrane or membrane transporters. The relative role played by these distinct processes remains actively debated. Moreover, the role of membrane‐trafficking in drug transport remains underappreciated and unexplored. Here we discuss the distinct processes involved in cellular drug distribution and propose that better experimental models are required to elucidate the differential contributions of various processes in intracellular drug accumulation.