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Quantitative Systems Pharmacology: A Case for Disease Models
Author(s) -
Musante CJ,
Ramanujan S,
Schmidt BJ,
Ghobrial OG,
Lu J,
Heatherington AC
Publication year - 2017
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt.528
Subject(s) - clinical pharmacology , systems pharmacology , pharmacology , medicine , computational biology , intensive care medicine , biology , drug
Quantitative systems pharmacology (QSP) has emerged as an innovative approach in model‐informed drug discovery and development, supporting program decisions from exploratory research through late‐stage clinical trials. In this commentary, we discuss the unique value of disease‐scale “platform” QSP models that are amenable to reuse and repurposing to support diverse clinical decisions in ways distinct from other pharmacometrics strategies.