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The plasma membrane monoamine transporter (PMAT): Structure, function, and role in organic cation disposition
Author(s) -
Wang J
Publication year - 2016
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt.442
Subject(s) - monoamine neurotransmitter , transporter , xenobiotic , organic cation transport proteins , chemistry , pharmacology , biochemistry , biology , enzyme , gene , serotonin , receptor
Plasma membrane monoamine transporter (PMAT) is a new polyspecific organic cation transporter that transports a variety of biogenic amines and xenobiotic cations. Highly expressed in the brain, PMAT represents a major uptake 2 transporter for monoamine neurotransmitters. At the blood–cerebrospinal fluid (CSF) barrier, PMAT is the principal organic cation transporter for removing neurotoxins and drugs from the CSF. Here I summarize our latest understanding of PMAT and its roles in monoamine uptake and xenobiotic disposition.