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Imaging transporters: Transforming diagnostic and therapeutic development
Author(s) -
Mann A,
Han H,
Eyal S
Publication year - 2016
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt.416
Subject(s) - transporter , molecular imaging , drug development , computational biology , pharmacology , neuroscience , medicine , function (biology) , drug , drug discovery , modalities , bioinformatics , biology , microbiology and biotechnology , gene , biochemistry , in vivo , social science , sociology
Molecular imaging allows noninvasive assessment of drug distribution across pharmacological barriers. Thus, it plays an increasingly important role in efforts to understand the interactions of molecules with membrane transporters during drug development and in clinical pharmacology. We describe established and emerging imaging modalities utilized for studying transporter expression and function. We further present examples of how molecular imaging could provide insights into the contribution of transporters to drug disposition and effects.