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Pregnancy‐related pharmacokinetic changes
Author(s) -
Tasnif Y,
Morado J,
Hebert MF
Publication year - 2016
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt.382
Subject(s) - pharmacokinetics , pregnancy , drug , drug metabolism , pharmacology , transporter , medicine , drugs in pregnancy , renal function , distribution (mathematics) , endocrinology , physiology , fetus , chemistry , biology , biochemistry , mathematical analysis , genetics , mathematics , gene
The pharmacokinetics of many drugs are altered by pregnancy. Drug distribution and protein binding are changed by pregnancy. While some drug metabolizing enzymes have an apparent increase in activity, others have an apparent decrease in activity. Not only is drug metabolism affected by pregnancy, but renal filtration is also increased. In addition, pregnancy alters the apparent activities of multiple drug transporters resulting in changes in the net renal secretion of drugs.