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Physiologically based pharmacokinetic modeling in drug discovery and development: A pharmaceutical industry perspective
Author(s) -
Jones HM,
Chen Y,
Gibson C,
Heimbach T,
Parrott N,
Peters SA,
Snoeys J,
Upreti VV,
Zheng M,
Hall SD
Publication year - 2015
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt.37
Subject(s) - physiologically based pharmacokinetic modelling , pharmaceutical industry , perspective (graphical) , drug development , drug discovery , management science , pharmaceutical sciences , pharmacokinetics , computer science , drug , risk analysis (engineering) , pharmacology , biochemical engineering , business , medicine , engineering , chemistry , artificial intelligence , biochemistry
The application of physiologically based pharmacokinetic (PBPK) modeling has developed rapidly within the pharmaceutical industry and is becoming an integral part of drug discovery and development. In this study, we provide a cross pharmaceutical industry position on “how PBPK modeling can be applied in industry” focusing on the strategies for application of PBPK at different stages, an associated perspective on the confidence and challenges, as well as guidance on interacting with regulatory agencies and internal best practices.