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Epigenetics in Drug Response
Author(s) -
Cascorbi I,
Schwab M
Publication year - 2016
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt.349
Subject(s) - epigenetics , histone , dna methylation , biology , drug action , drug , drug response , epigenetic regulation of neurogenesis , acetylation , phenotype , computational biology , genetics , epigenesis , bioinformatics , dna , gene expression , pharmacology , gene , histone methyltransferase
Hereditary genetic variation has been identified to contribute significantly to drug response. More recently, there is increasing evidence that individual phenotypic differences may also result from epigenetic alterations such as histone‐acetylation or DNA‐methylation. Moreover, interactions with noncoding RNAs contribute to protein expression and may modulate drug action. Currently, intriguing developments of novel therapeutic approaches through epigenetic drugs are emerging. The overall complexity of epigenetics in drug action, however, is so far only little understood.