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Intestinal Microbiota in Inflammatory Bowel Disease and Carcinogenesis: Implication for Therapeutics
Author(s) -
Bruner SD,
Jobin C
Publication year - 2016
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt.348
Subject(s) - inflammatory bowel disease , microbiome , colorectal cancer , host (biology) , intestinal microbiome , disease , inflammatory bowel diseases , biology , carcinogenesis , immunology , cancer , medicine , bioinformatics , pathology , genetics
Trillions of bacteria inhabit our intestine, forming a community called the microbiota, whose contributions are essential to maintain host homeostasis. Disruption of this normal microbial‐host communication network has deleterious consequences for the host and is associated with intestinal pathologies such as inflammatory bowel diseases (IBD) and colorectal cancer (CRC). Here we present key concepts and mechanisms by which bacteria may participate in intestinal pathology, and discuss possible means to therapeutically target the microbiome.