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DNA Methylation of ADME Genes
Author(s) -
Fisel P,
Schaeffeler E,
Schwab M
Publication year - 2016
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt.343
Subject(s) - adme , epigenetics , dna methylation , biology , microrna , gene , histone , computational biology , gene expression , epigenomics , methylation , genetics , drug , pharmacology
The epigenetic regulation of expression of genes involved in the absorption, distribution, metabolism, and excretion (ADME) of drugs contributes to interindividual variability in drug response. Epigenetic mechanisms include DNA methylation, histone modifications, and miRNAs. This review systematically outlines the influence of DNA methylation on ADME gene expression and highlights the consequences for interindividual variability in drug response or drug‐induced toxicity and the implications for personalized medicine.