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Clinical relevance of cyclic GMP modulators: A translational success story of network pharmacology
Author(s) -
Oettrich JM,
Dao VT,
Frijhoff J,
Kleikers PWM,
Casas AI,
Hobbs AJ,
Schmidt HHHW
Publication year - 2016
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt.336
Subject(s) - interchangeability , clinical pharmacology , cyclic gmp , cyclic guanosine monophosphate , pharmacology , medicine , guanosine , relevance (law) , systems pharmacology , neuroscience , drug , biology , computer science , endocrinology , genetics , nitric oxide , political science , law , programming language
Therapies that modulate cyclic guanosine‐3′‐5′‐monophosphate (cGMP) have emerged as one of the most successful areas in recent drug discovery and clinical pharmacology. Historically, their focus has been on cardiovascular disease phenotypes; however, cGMP's relevance is likely to go beyond this rather limited organ‐based set of indications. Moreover, the multitude of targets and their apparent interchangeability is a proof‐of‐concept of network pharmacology.