Premium
Correction of aberrant imprinting by allele‐specific epigenome editing
Author(s) -
Bashtrykov P,
Kungulovski G,
Jeltsch A
Publication year - 2016
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt.295
Subject(s) - imprinting (psychology) , genomic imprinting , dna methylation , epigenetics , genetics , epigenome , biology , allele , computational biology , crispr , gene , gene expression
Imprinting disorders are caused by the loss of the normal allele‐specific DNA methylation at imprinting centers. Epigenetic editing is a promising approach to alter DNA methylation at defined genomic target regions. The novel development of CRISPR‐Cas9‐based DNA binding domains may allow for an allele‐specific editing of DNA methylation at imprinted loci, for the first time offering a rational approach for correction of the molecular defects in imprinting disorders.