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Integrated patient and tumor genetic testing for individualized cancer therapy
Author(s) -
Hertz DL,
McLeod HL
Publication year - 2016
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt.294
Subject(s) - genome , identification (biology) , medicine , selection (genetic algorithm) , cancer , drug , cancer treatment , computational biology , oncology , bioinformatics , biology , gene , genetics , pharmacology , computer science , botany , artificial intelligence
Tumor genome analysis is transforming cancer treatment by enabling identification of specific oncogenic drivers and selection of effective targeted agents. Meanwhile, patient genome analysis is being employed across therapeutic areas to inform selection of appropriate drugs and doses for treatment safety. Integration of patient genome analysis concurrent with preemptive tumor genetic testing will enable oncologists to make informed treatment decisions to select the right dose of the right drug for each patient and their tumor.