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Ignorance is not bliss: Statistical power is not probability of trial success
Author(s) -
Zierhut ML,
Bycott P,
Gibbs MA,
Smith BP,
Vicini P
Publication year - 2016
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt.257
Subject(s) - bliss , dialog box , ignorance , context (archaeology) , clinical trial , drug development , statistical power , computer science , management science , risk analysis (engineering) , medicine , medical physics , drug , epistemology , pharmacology , engineering , statistics , mathematics , paleontology , philosophy , world wide web , biology , programming language
The purpose of this commentary is to place probability of trial success, or assurance, in the context of decision making in drug development, and to illustrate its properties in an intuitive manner for the readers of Clinical Pharmacology and Therapeutics . The hope is that this will stimulate a dialog on how assurance should be incorporated into a quantitative decision approach for clinical development and trial design that uses all available information.