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Inhibition of Antiplatelet Effects of Aspirin by Nonopioid Analgesics
Author(s) -
Hohlfeld T,
Schrör K
Publication year - 2015
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt.21
Subject(s) - aspirin , medicine , platelet , drug , pharmacology , analgesic , antiplatelet drug , anesthesia , drug interaction , platelet aggregation inhibitor , platelet aggregation , clopidogrel
In patients undergoing coronary bypass grafting, we noticed that low‐dose aspirin failed to inhibit platelet aggregation, potentially elevating the risk of thrombotic bypass occlusion. This “high on‐treatment platelet reactivity” was reproducible in vitro and could be transferred with patient plasma or urine to aspirin‐sensitive donor platelets, suggesting a drug/drug interaction. Loss of aspirin efficacy was associated with analgesia by dipyrone (metamizol) and initiated further study of the interaction between aspirin and other nonopioid analgesics.