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PharmVar GeneFocus: CYP2C19
Author(s) -
Botton Mariana R.,
WhirlCarrillo Michelle,
Del Tredici Andria L.,
Sangkuhl Katrin,
Cavallari Larisa H.,
Agúndez José A. G.,
Duconge Jorge,
Lee Ming Ta Michael,
Woodahl Erica L.,
ClaudioCampos Karla,
Daly Ann K.,
Klein Teri E.,
Pratt Victoria M.,
Scott Stuart A.,
Gaedigk Andrea
Publication year - 2021
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt.1973
Subject(s) - pharmacogenomics , cyp2c19 , pharmacogenetics , haplotype , allele , genetic variation , computational biology , medicine , bioinformatics , genetics , biology , gene , genotype
The Pharmacogene Variation Consortium (PharmVar) catalogues star (*) allele nomenclature for the polymorphic human CYP2C19 gene. CYP2C19 genetic variation impacts the metabolism of many drugs and has been associated with both efficacy and safety issues for several commonly prescribed medications. This GeneFocus provides a comprehensive overview and summary of CYP2C19 and describes how haplotype information catalogued by PharmVar is utilized by the Pharmacogenomics Knowledgebase and the Clinical Pharmacogenetics Implementation Consortium (CPIC).