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Human Ontogeny of Drug Transporters: Review and Recommendations of the Pediatric Transporter Working Group
Author(s) -
Brouwer KLR,
Aleksunes LM,
Brandys B,
Giacoia GP,
Knipp G,
Lukacova V,
Meibohm B,
Nigam SK,
Rieder M,
de Wildt SN
Publication year - 2015
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt.176
Subject(s) - transporter , pharmacotherapy , ontogeny , biology , pharmacology , drug , medicine , bioinformatics , biochemistry , endocrinology , gene
The critical importance of membrane‐bound transporters in pharmacotherapy is widely recognized, but little is known about drug transporter activity in children. In this white paper, the Pediatric Transporter Working Group presents a systematic review of the ontogeny of clinically relevant membrane transporters (e.g., SLC, ABC superfamilies) in intestine, liver, and kidney. Different developmental patterns for individual transporters emerge, but much remains unknown. Recommendations to increase our understanding of membrane transporters in pediatric pharmacotherapy are presented.