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Organs‐on‐Chips in Clinical Pharmacology: Putting the Patient Into the Center of Treatment Selection and Drug Development
Author(s) -
Peck Richard W.,
Hinojosa Christopher D.,
Hamilton Geraldine A.
Publication year - 2020
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt.1688
Subject(s) - drug development , drug , workflow , medicine , intensive care medicine , regimen , clinical pharmacology , selection (genetic algorithm) , medical physics , pharmacology , risk analysis (engineering) , computer science , artificial intelligence , database
There have been rapid advances since Organs‐on‐Chips were first developed. Organ‐Chips are now available beyond academic laboratories with the initial emphasis to reduce animal experimentation and improve predictability of drug development through better prediction of safety and efficacy. There is now a huge opportunity to use chips to understand efficacy and disease variability. We propose that by 2030, Organs‐on‐Chips will play a key role in clinical pharmacology as part of the diagnostic and treatment workflow for some diseases by informing the right drug and dose regimen for each patient.