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PharmVar GeneFocus: CYP2D6
Author(s) -
Nofziger Charity,
Turner Amy J.,
Sangkuhl Katrin,
WhirlCarrillo Michelle,
Agúndez José A.G.,
Black John L.,
Dunnenberger Henry M.,
Ruano Gualberto,
Kennedy Martin A.,
Phillips Michael S.,
Hachad Houda,
Klein Teri E.,
Gaedigk Andrea
Publication year - 2020
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt.1643
Subject(s) - pharmacogenomics , cyp2d6 , pharmacogenetics , genetic variation , locus (genetics) , variation (astronomy) , computational biology , biology , bioinformatics , genetics , gene , genotype , physics , astrophysics
The Pharmacogene Variation Consortium (PharmVar) provides nomenclature for the highly polymorphic human CYP2D6 gene locus. CYP2D6 genetic variation impacts the metabolism of numerous drugs and, thus, can impact drug efficacy and safety. This GeneFocus provides a comprehensive overview and summary of CYP2D6 genetic variation and describes how the information provided by PharmVar is utilized by the Pharmacogenomics Knowledgebase (PharmGKB) and the Clinical Pharmacogenetics Implementation Consortium (CPIC).