PharmVar GeneFocus:  CYP2D6 | Zendy

Nofziger Charity | Zendy; Turner Amy J. | Zendy; Sangkuhl Katrin | Zendy; WhirlCarrillo Michelle | Zendy; Agúndez José A.G. | Zendy; Black John L. | Zendy; Dunnenberger Henry M. | Zendy; Ruano Gualberto | Zendy; Kennedy Martin A. | Zendy; Phillips Michael S. | Zendy; Hachad Houda | Zendy; Klein Teri E. | Zendy; Gaedigk Andrea | Zendy

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PharmVar GeneFocus: CYP2D6

Author(s) -

Nofziger Charity,

Turner Amy J.,

Sangkuhl Katrin,

WhirlCarrillo Michelle,

Agúndez José A.G.,

Black John L.,

Dunnenberger Henry M.,

Ruano Gualberto,

Kennedy Martin A.,

Phillips Michael S.,

Hachad Houda,

Klein Teri E.,

Gaedigk Andrea

Publication year - 2020

Publication title -

clinical pharmacology and therapeutics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.941

H-Index - 188

eISSN - 1532-6535

pISSN - 0009-9236

DOI - 10.1002/cpt.1643

Subject(s) - pharmacogenomics , cyp2d6 , pharmacogenetics , genetic variation , computational biology , locus (genetics) , variation (astronomy) , biology , bioinformatics , genetics , gene , genotype , physics , astrophysics

The Pharmacogene Variation Consortium (PharmVar) provides nomenclature for the highly polymorphic human CYP2D6 gene locus. CYP2D6 genetic variation impacts the metabolism of numerous drugs and, thus, can impact drug efficacy and safety. This GeneFocus provides a comprehensive overview and summary of CYP2D6 genetic variation and describes how the information provided by PharmVar is utilized by the Pharmacogenomics Knowledgebase (PharmGKB) and the Clinical Pharmacogenetics Implementation Consortium (CPIC).

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