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Progress of Pharmacological Approaches in Parkinson's Disease
Author(s) -
Zeuner Kirsten E.,
Schäffer Eva,
Hopfner Franziska,
Brüggemann Norbert,
Berg Daniela
Publication year - 2019
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt.1374
Subject(s) - parkinson's disease , neuroinflammation , disease , neuroscience , dopaminergic , alpha synuclein , medicine , clinical trial , central nervous system , bioinformatics , dopamine , biology , pathology
The progressive neurodegenerative process in Parkinson's disease (PD) is not restricted to dopaminergic midbrain neurons but involves the entire nervous system. In this review, we outline established treatment options at different disease stages and address new therapeutic approaches. These include, based on recent advances in the understanding of the pathophysiology of PD, genetic and disease‐modifying approaches to reduce abnormal accumulation and aggregation of alpha‐synuclein (aSYN), mitochondrial dysfunction, and dysfunction of lysosomal proteins. Moreover, we highlight clinical trials to reduce neuroinflammation and increase neurorestoration.