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Regenerative Prophylaxis In Utero
Author(s) -
Ruano Rodrigo,
Enninga Elizabeth Ann L.,
Brana Rivera Paola E.,
Terzic Andre
Publication year - 2019
Publication title -
clinical pharmacology and therapeutics
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt.1262
Subject(s) - in utero , medicine , pharmacology , pregnancy , biology , fetus , genetics
Technology advances have raised the outlook for regenerative solutions aimed at restoring organ health. Fetal surgery, implemented to reinstate early organ growth and restitute function in select congenital conditions, is increasingly considered with the prospect of improved postnatal outcomes. Herein, we highlight clinical prenatal interventions for rescue of fetal lung development in congenital diaphragmatic hernia and fetal neurological regeneration for spina bifida. Regenerative therapeutic care in utero is poised to transform management algorithms.