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Cannabinoid abuse and addiction: Clinical and preclinical findings
Author(s) -
Panlilio LV,
Goldberg SR,
Justinova Z
Publication year - 2015
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt.118
Subject(s) - addiction , cannabinoid , drugs of abuse , medicine , pharmacotherapy , psychiatry , adverse effect , substance abuse , cannabis , cannabinoid receptor , pharmacology , psychology , receptor , agonist
Cannabinoid abuse disorders represent a widespread public health issue, but there are no approved medications for their treatment. This review describes efforts to understand the mechanisms of cannabinoid abuse and its adverse effects, to identify molecular targets for pharmacotherapy, and to evaluate potential treatments in human volunteers and animal models of cannabinoid reward, withdrawal, and relapse.