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Physiologically Based Pharmacokinetic Modeling in Pregnancy: A Systematic Review of Published Models
Author(s) -
Dallmann André,
Pfister Marc,
van den Anker John,
Eissing Thomas
Publication year - 2018
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt.1084
Subject(s) - physiologically based pharmacokinetic modelling , pharmacokinetics , pregnancy , medicine , computer science , pharmacology , biology , genetics
During recent years there has been a surge in developing and applying physiologically based pharmacokinetic (PBPK) models in pregnant women to better understand and predict changes in drug pharmacokinetics throughout pregnancy. As a consequence, the number of publications focusing on pregnancy PBPK models has increased substantially. However, to date these models, especially across various platforms, have not been systematically evaluated. Hence, this review aims to assess published PBPK models in pregnancy used for therapeutic purposes.