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Effect of dipyridamole on myocardial reperfusion injury: A double‐blind randomized controlled trial in patients undergoing elective coronary artery bypass surgery
Author(s) -
El Messaoudi S,
Wouters CW,
van Swieten HA,
Pickkers P,
Noyez L,
Kievit PC,
Abbink EJ,
RasingHoogveld A,
Bouw TP,
Peters JG,
Coenen MJH,
Donders ART,
Riksen NP,
Rongen GA
Publication year - 2016
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt.106
Subject(s) - dipyridamole , medicine , cardiology , anesthesia , coronary artery disease , clinical endpoint , placebo , artery , troponin i , randomized controlled trial , troponin , angioplasty , myocardial infarction , alternative medicine , pathology
Dipyridamole reduces reperfusion‐injury in preclinical trials and may be beneficial in patients undergoing coronary angioplasty, but its effect on patients undergoing coronary artery bypass grafting (CABG) is unknown. We hypothesized that dipyridamole limits myocardial reperfusion‐injury in patients undergoing CABG. The trial design was a double‐blind trial randomizing between pretreatment with dipyridamole or placebo. In all, 94 patients undergoing elective on‐pump CABG were recruited between February 2010 and June 2012. The primary endpoint was plasma high‐sensitive (hs‐) troponin‐I at 6, 12, and 24 hours after reperfusion. Secondary endpoints were the occurrence of bleeding, arrhythmias, need for inotropic support, and intensive care unit length of stay. Finally, 79 patients (33 dipyridamole) were included in the per‐protocol analysis. Dipyridamole did not significantly affect postoperative hs‐troponin‐I (change in plasma hs‐troponin I −3% [95% confidence interval −23% to 36%]; P > 0.1). Secondary endpoints did not differ between groups. Dipyridamole prior to CABG does not significantly reduce postoperative hs‐troponin release.