Role of High‐Throughput Electrophysiology in Drug Discovery | Zendy

Liu Chang | Zendy; Li Tianbo | Zendy; Chen Jun | Zendy

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Role of High‐Throughput Electrophysiology in Drug Discovery

Author(s) -

Liu Chang,

Li Tianbo,

Chen Jun

Publication year - 2019

Publication title -

current protocols in pharmacology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.893

H-Index - 26

eISSN - 1934-8290

pISSN - 1934-8282

DOI - 10.1002/cpph.69

Subject(s) - drug discovery , electrophysiology , ion channel , bottleneck , throughput , high throughput screening , computer science , neuroscience , biology , bioinformatics , telecommunications , biochemistry , receptor , wireless , embedded system

Due to their important physiological functions, ion channels are key therapeutic targets for a variety of disorders. However, electrophysiological assessment of ion channel activity is technically challenging and has been a bottleneck in the discovery of drugs that modulate channel function. To address this issue, automated patch clamp platforms have been developed with improved throughput and broader applications. An overview of the current status of high‐throughput electrophysiology and its applications in drug discovery is provided. © 2019 The Authors.

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