Open AccessRole of High‐Throughput Electrophysiology in Drug Discovery
Author(s) -
Liu Chang,
Li Tianbo,
Chen Jun
Publication year - 2019
Publication title -
current protocols in pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.893
H-Index - 26
eISSN - 1934-8290
pISSN - 1934-8282
DOI - 10.1002/cpph.69
Subject(s) - drug discovery , electrophysiology , ion channel , bottleneck , throughput , high throughput screening , computer science , neuroscience , biology , bioinformatics , telecommunications , biochemistry , receptor , wireless , embedded system
Abstract Due to their important physiological functions, ion channels are key therapeutic targets for a variety of disorders. However, electrophysiological assessment of ion channel activity is technically challenging and has been a bottleneck in the discovery of drugs that modulate channel function. To address this issue, automated patch clamp platforms have been developed with improved throughput and broader applications. An overview of the current status of high‐throughput electrophysiology and its applications in drug discovery is provided. © 2019 The Authors.