Premium
Front Cover: Proton Transfer and S N 2 Reactions as Steps of Fast Selenol and Thiol Oxidation in Proteins: A Model Molecular Study Based on GPx (ChemPlusChem 4/2021)
Author(s) -
Dalla Tiezza Marco,
Bickelhaupt F. Matthias,
Flohé Leopold,
Orian Laura
Publication year - 2021
Publication title -
chempluschem
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 0.801
H-Index - 61
ISSN - 2192-6506
DOI - 10.1002/cplu.202100007
Subject(s) - front cover , chemistry , thiol , sulfur , selenium , cover (algebra) , organic chemistry , mechanical engineering , engineering
The Front Cover shows two lorries along the road directed to ‘H 2 O 2 reduction’ destination. The selenol (SeH) lorry is in front, being faster than the thiol (SH) lorry. This cartoon represents the situation of glutathione peroxidase, in which the presence of selenium rather than sulfur warrants a significantly faster hydroperoxide reduction along the same mechanistic path. This can be explained on the basis of the chemistry of the two chalcogens as illustrated in our paper. More information can be found in the Full Paper by L. Orian and co‐workers.