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Gadolinium Complexes Attached to Poly Ethoxy Ethyl Glycinamide (PEE‐G) Dendrons: Magnetic Resonance Imaging Contrast Agents with Increased Relaxivity
Author(s) -
Shrestha Rinu,
TeesdaleSpittle Paul H.,
Lewis Andrew R.,
Rendle Phillip M.
Publication year - 2020
Publication title -
chempluschem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.801
H-Index - 61
ISSN - 2192-6506
DOI - 10.1002/cplu.202000409
Subject(s) - gadolinium , chemistry , dendrimer , magnetic resonance imaging , nuclear magnetic resonance , alkoxy group , polymer chemistry , organic chemistry , radiology , medicine , physics , alkyl
A range of poly ethoxy ethyl glycinamide (PEE−G) dendron scaffolds with gadolinium (III) complexes attached were synthesized with a focus on product purity and high Gd(III) loading. The nuclear magnetic resonance relaxivity of these products was measured and compared with commercially available low‐molecular‐weight magnetic resonance imaging contrast agents. Over twice the relaxivity based on Gd(III) concentration, and up to 20‐fold increase in relaxivity were observed based on molecular concentration. Relaxivity properties were observed to increase with both increasing molecular weight and number of Gd(III) complexes attached, however a plateau was reached for molecular weight increase. T 1 and T 2 relaxivity properties were also investigated at two different magnetic fields. Transverse relaxivity is unaffected by magnetic field strength whereas increase in longitudinal relaxivity was not as pronounced at the higher field.