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Front Cover: Bioorthogonal Phosphorogenic Rhenium(I) Polypyridine Sydnone Complexes for Specific Lysosome Labeling (ChemPlusChem 7/2020)
Author(s) -
Shum Justin,
Zhang PeiZhi,
Lee Lawrence ChoCheung,
Lo Kenneth KamWing
Publication year - 2020
Publication title -
chempluschem
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 0.801
H-Index - 61
ISSN - 2192-6506
DOI - 10.1002/cplu.202000356
Subject(s) - bioorthogonal chemistry , chemistry , rhenium , front cover , moiety , alkyne , sydnone , combinatorial chemistry , nanotechnology , click chemistry , stereochemistry , cover (algebra) , organic chemistry , mechanical engineering , ring (chemistry) , engineering , materials science , catalysis
The Front Cover shows the selective landing of a bioorthogonal spacecraft on a lysosomal planet that is modified with a strained cyclooctyne moiety in an intracellular environment with other organelles and a plethora of biomolecules. A sydnone moiety is appended to a luminescent rhenium(I) diimine unit as both an emission quencher and a bioorthogonal handle. Selective strain‐promoted sydnone–alkyne cycloaddition (SPSAC) of the complex with a strained alkyne leads to impressive emission turn‐on, which can be exploited for bioimaging and phototherapeutic applications. More information can be found in the Full Paper by K. K.‐W. Lo and co‐workers (DOI: 10.1002/cplu.202000029). (Graphics Design: Michael W.‐L. Chiang).