Premium
Theoretical and Experimental Studies on the Near‐Infrared Photoreaction Mechanism of a Silicon Phthalocyanine Photoimmunotherapy Dye: Photoinduced Hydrolysis by Radical Anion Generation
Author(s) -
Kobayashi Masato,
Harada Mei,
Takakura Hideo,
Ando Kanta,
Goto Yuto,
Tsuneda Takao,
Ogawa Mikako,
Taketsugu Tetsuya
Publication year - 2020
Publication title -
chempluschem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.801
H-Index - 61
ISSN - 2192-6506
DOI - 10.1002/cplu.202000338
Subject(s) - chemistry , dissociation (chemistry) , photochemistry , ligand (biochemistry) , molecule , organic chemistry , biochemistry , receptor
Ligand release from IR700, a silicon phthalocyanine dye used in near‐infrared (NIR) photoimmunotherapy, initiates cancer cell death after NIR absorption, although its photochemical mechanism has remained unclear. This theoretical study reveals that the direct Si‐ligand dissociation by NIR light is difficult to activate because of the high dissociation energy even in excited states, i. e., >1.30 eV. Instead, irradiation generates the IR700 radical anion, leading to acid‐base reactions with nearby water molecules (i. e., calculated pK b for the radical anion is 7.7) to produce hydrophobic ligand‐released dyes. This suggests two possibilities: (1) water molecules participate in ligand release and (2) light is not required for Si–ligand dissociation as formation of the IR700 radical anion is sufficient. Experimental evidence confirmed possibility (1) by using 18 O‐labeled water as the solvent, while (2) is supported by the pH dependence of ligand exchange, providing a complete description of the Si‐ligand bond dissociation mechanism.