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Cover Feature: Rh(III)‐Catalyzed Redox‐Neutral [4+2] Annulation for Direct Assembly of 3‐Acyl Isoquinolin‐1(2 H )‐ones as Potent Antitumor Agents (ChemPlusChem 3/2020)
Author(s) -
Bian Mengyao,
Ma Lei,
Wu Min,
Wu Liexin,
Gao Hui,
Yi Wei,
Zhang Chao,
Zhou Zhi
Publication year - 2020
Publication title -
chempluschem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.801
H-Index - 61
ISSN - 2192-6506
DOI - 10.1002/cplu.202000008
Subject(s) - chemistry , annulation , ring (chemistry) , redox , propargyl , catalysis , rhodium , cover (algebra) , combinatorial chemistry , stereochemistry , medicinal chemistry , organic chemistry , mechanical engineering , engineering
The cover feature shows a new and efficient rhodium(III)‐catalyzed redox‐neutral C−H activation/ring‐opening of strained ring/[4+2] annulation cascade of N ‐methoxybenzamides with propargyl cycloalkanols, providing a direct access to diverse 3‐acyl isoquinolin‐1(2 H )‐ones as potential anti‐lung‐cancer drugs. These antitumor agents can powerfully inhibit proliferation and induce apoptosis. More details can be found in the Full Paper by Yi, Zhang, Zhou, and co‐workers on page 405 in Issue 3, 2020 (DOI: 10.1002/cplu.201900616).