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Derivatized Carbon Nanotubes for Gene Therapy in Mammalian and Plant Cells
Author(s) -
Singh Adhish,
Hua Hsu Ming,
Gupta Neeraj,
Khanra Partha,
Kumar Pankaj,
Prakash Verma Ved,
Kapoor Mohit
Publication year - 2020
Publication title -
chempluschem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.801
H-Index - 61
ISSN - 2192-6506
DOI - 10.1002/cplu.201900678
Subject(s) - genetic enhancement , carbon nanotube , gene , gene silencing , nanotechnology , viral vector , computational biology , dna , suicide gene , surface modification , gene delivery , vector (molecular biology) , chemistry , rna , biology , biochemistry , materials science , recombinant dna
The concept of gene vectors for therapeutic applications has been known for several years, but it is far from revealing its actual potential. With the advent of hollow cylindrical carbon nanomaterials such as carbon nanotubes (CNTs), researchers have invented several new tools to deliver genes at the required site of action in mammalian and plant cells. The ease of diversified functionalization has allowed CNTs to be by far the most adaptable non‐viral vector for gene therapy. This Minireview addresses the dexterity with which CNTs undergo surface modifications and their applications as a potent vector in gene therapy of humans and plants. Specifically, we will discuss the new tools that scientific communities have invented to achieve gene therapy using plasmid DNA, RNA silencing, suicide gene therapy, and plant genetic engineering. Additionally, we will shed some light on the mechanism of gene transportation using carbon nanotubes in cancer cells and plants.