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trans‐Platinum(II) Thionate Complexes: Synthesis, Structural Characterization, and in vitro Biological Assessment as Potent Anticancer Agents
Author(s) -
Sakamaki Yoshie,
Ahmadi Mirsadeghi Hasti,
Fereidoonnezhad Masood,
Mirzaei Faezeh,
Moghimi Dehkordi Zahra,
Chamyani Samira,
Alshami Mia,
Abedanzadeh Sedigheh,
Shahsavari Hamid R.,
Beyzavi M. Hassan
Publication year - 2019
Publication title -
chempluschem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.801
H-Index - 61
ISSN - 2192-6506
DOI - 10.1002/cplu.201900394
Subject(s) - benzothiazole , thiol , chemistry , cisplatin , benzimidazole , pyridine , comet assay , stereochemistry , in vitro , pyrimidine , apoptosis , dna damage , biochemistry , dna , medicinal chemistry , organic chemistry , biology , genetics , chemotherapy
A series of Pt(II) complexes trans ‐[Pt(PPh 2 allyl) 2 ( κ 1 ‐S‐SR) 2 ], 1 , PPh 2 allyl=allyldiphenylphosphine, SR=pyridine‐2‐thiol (Spy, 1 a ), 5‐(trifluoromethyl)‐pyridine‐2‐thiol (SpyCF 3 ‐5, 1 b ), pyrimidine‐2‐thiol (SpyN, 1 c ), benzothiazole‐2‐thiol (Sbt, 1 d ), benzimidazole‐2‐thiol (Sbi, 1 e ), were synthesized. They were characterized by NMR, HR ESI‐MS, and X‐ray crystallography. Treatment of human cancer cell lines (A549, SKOV3, MCF‐7) with these complexes resulted in promising antitumor effects in comparison with cisplatin. These compounds showed suitable selectivity between tumorigenic and non‐tumorigenic (MCF‐10 A) cell lines. Analyses of cell cycle progression and apoptosis were conducted for 1 a , the most cytotoxic compound, to screen dose/time response and to study the antiproliferative mechanism. An electrophoresis mobility shift assay was performed to assess the direct interaction of 1 a with DNA and the strong genotoxic ability was indicated through the comet assay method.