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Hydrophilic Porous Poly( l ‐Lactic Acid) Nanomembranes: Self‐Assembly, and Anti‐Biofouling and Anti‐Thrombosis Effects
Author(s) -
Deng Xiulong,
Zhang Mengbi,
Tan Lishan,
Zeng Tao,
Lai Xuandi,
Geng Xinran,
Huang Caili,
Li Aiqing,
Pan Yanchao,
Hu Jianqiang
Publication year - 2019
Publication title -
chempluschem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.801
H-Index - 61
ISSN - 2192-6506
DOI - 10.1002/cplu.201900256
Subject(s) - contact angle , biofouling , materials science , porosity , peg ratio , chemical engineering , drug delivery , adsorption , nanotechnology , composite material , chemistry , organic chemistry , membrane , biochemistry , finance , engineering , economics
Hydrophilic PEGylated porous self‐assembled nanomembranes (PSANMs) with average thickness and pore diameter of ca . 10 and 20–24 nm were successfully prepared by an emulsification‐induced programmable self‐assembly strategy. The hydrophilicity, anti‐biofouling, and anti‐thrombosis properties of PEGylated PSANMs were largely improved in comparison with the nonfunctionalized PSANMs, which could transform into hydrophilic (PEGylated PSANMs, minimum water contact angle: 38.8°) from hydrophobic units (PSANMs, maximum water contact angle: 137.5°) with increasing PEG density and length. The total protein adsorption of PEGylated PSANMs was about six times lower than that of the PSANMs, while the thrombosis of the PEGylated PSANMs (maximum R‐time: 5.37 min) was also greatly relieved in comparison with the PSANMs (minimum R‐time: 2.93 min). Such PEG‐modified PSANMs may have applications in drug delivery and tissue and organ repair in vivo .