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Multifunctional Clickable Reagents for Rapid Bioorthogonal Astatination and Radio‐Crosslinking
Author(s) -
Denk Christoph,
Wilkovitsch Martin,
Aneheim Emma,
Herth Matthias M.,
Jensen Holger,
Lindegren Sture,
Mikula Hannes
Publication year - 2019
Publication title -
chempluschem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.801
H-Index - 61
ISSN - 2192-6506
DOI - 10.1002/cplu.201900250
Subject(s) - bioorthogonal chemistry , reagent , click chemistry , chemistry , combinatorial chemistry , cover (algebra) , nanotechnology , materials science , organic chemistry , mechanical engineering , engineering
Invited for this month's cover is the group of Dr. Hannes Mikula at Vienna University of Technology (TU Wien), Austria. The cover picture shows immobilized astatine‐labeled reagents that have been sterically shielded with polyethylene chains by rapid bioorthogonal ligation leading to increased stability of the radiolabel in biological media. These multifunctional and bioorthogonal 211 At reagents can be efficiently prepared by rapid click assembly and simultaneous astatination. Read the full text of the article at 10.1002/cplu.201900114.