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Tandem Systems for Two‐Photon Uncaging of Bioactive Molecules
Author(s) -
Klausen Maxime,
Dubois Victor,
Verlhac JeanBaptiste,
BlanchardDesce Mireille
Publication year - 2019
Publication title -
chempluschem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.801
H-Index - 61
ISSN - 2192-6506
DOI - 10.1002/cplu.201900139
Subject(s) - förster resonance energy transfer , tandem , nanotechnology , modular design , electron transfer , photon , energy transfer , chemistry , quantum yield , materials science , computer science , photochemistry , fluorescence , physics , chemical physics , optics , composite material , operating system
Photodeprotection of biological ligands with the combination of photolabile protecting groups (PPGs) and two‐photon (2P) excitation techniques offers the possibility to control physiological phenomena with utmost spatial and temporal precision. Yet, designing PPGs with sufficient 2P photosensitivity still remains challenging. Direct enhancement of the 2P absorption properties usually relies on modifications of the PPG structure, which sometimes results in unpredictable and counterproductive effects on the uncaging quantum yield. In that respect, combining known PPGs with a suitable two‐photon light‐harvesting antenna within a modular architecture offers a promising alternative. In this Minireview, we highlight this versatile strategy, with a discussion of different tandem 2P uncagers, relying on photoinduced electron transfer (PET), triplet‐ energy transfer (TT‐ET), or Förster resonance energy transfer (FRET) sensitization to enhance the 2P sensitivity of PPGs.