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Fabrication and Characterization of Hollow Microcapsules from Polyelectrolytes Bearing Thymine Pendant Groups for Ultraviolet‐B (UVB)‐Induced Crosslinking
Author(s) -
Giménez Rodrigo E.,
Serrano Mariana P.,
Álvarez Rosa María S.,
Martino Débora M.,
Borsarelli Claudio D.
Publication year - 2019
Publication title -
chempluschem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.801
H-Index - 61
ISSN - 2192-6506
DOI - 10.1002/cplu.201900131
Subject(s) - polyelectrolyte , materials science , thymine , polymer chemistry , chemical engineering , pyrimidine dimer , ultraviolet , chemistry , dna , polymer , composite material , biochemistry , optoelectronics , engineering , dna damage
Abstract DNA – bioinspired polyelectrolytes poly[vinylbenzylthymine (VBT)‐4‐vinylbenzyltriethylammonium chloride (VBA)] and poly[vinylbenzylthymine (VBT)‐4‐vinylphenylsufonate (VPS)] were used for the preparation of hollow microcapsules (HMC) using the layer‐by‐layer method and CaCO 3 microspheres as removable molds. Stable aqueous suspensions of spherical‐shaped HMCs with a shell composed of six layers of VBA‐based polyelectrolytes were obtained, of approximately (7.0±1.5) μm diameter and a shell thickness of 1 μm. Ultraviolet‐B irradiation of the HMC suspensions induces an efficient crosslinking between adjacent polyelectrolyte chains through the formation of thymine photodimers, such as the cyclobutane pyrimidine dimer (CPD) and the (6–4) pyrimidine–pyrimidone photoproduct (6–4PP). This process resulted in a reduction of the average interstitial mesh size of the HMC shells, modulating their permeability properties and increasing the mechanical stability of the HMC without a noticeable modification of size and shape. Thus, the DNA‐bioinspired polyelectrolytes are promising materials for the preparation of UVB‐responsive HMCs.