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Deciphering Block Copolymers as Carriers of a Pyrazoline Derivative through Its Solvatochromic Behavior: A Spectroscopic and Theoretical Exploration
Author(s) -
Singharoy Dipti,
Ghosh Swadesh,
Samai Boby,
Bhattacharya Subhash Chandra
Publication year - 2018
Publication title -
chempluschem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.801
H-Index - 61
ISSN - 2192-6506
DOI - 10.1002/cplu.201800449
Subject(s) - copolymer , solvatochromism , dispersity , solvent , materials science , molecule , polymer , fluorescence , miscibility , drug carrier , fluorescence spectroscopy , chemistry , polymer chemistry , drug delivery , organic chemistry , nanotechnology , physics , quantum mechanics
Many biologically active water‐insoluble drug molecules have limited clinical application because of strong hydrophobicity. Recently triblock copolymers have attracted enormous interest as potential drug carriers. For the purpose of delivering the 5‐(1‐(bromohexa‐1,3,5‐triyn‐1‐yl)‐3 a ,4,5,6,7,7 a ‐hexahydro‐1 H ‐4,7‐methanoindazol‐3‐yl)‐3‐methyl‐1‐phenyl‐1 H ‐pyrazole‐4‐carbonitrile (PYZ) molecule, triblock copolymers are used. In order to understand the delivery of this water‐insoluble probe through triblock copolymers (TBP), the solvent‐dependent fluorescence properties of this compound have been examined in different homogeneous solvents. Besides the experimental work, theoretical studies have also been conducted to explain actual orientation of atoms in PYZ through optimized structures to support the experimental findings. Moreover, the three TBP polymers P‐123 (PEO 19 PPO 69 PEO 19 ), F‐127 (PEO 100 PPO65PEO 100 ) and L‐64 (PEO 13 PPO 30 PEO 13 ) have been treated here as potential carriers that encapsulate a pyrazoline derivative. The consequence of spatial captivity on the emission properties was systematically visualized by means of steady‐state and time‐resolved fluorescence spectroscopy. From DLS measurements the size variation with the polydispersity index of TBP in the presence and absence of PYZ in different triblock copolymers was also monitored. Furthermore these measurements have been supported by TEM imaging also.