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A Galactose Dendritic Silicon (IV) Phthalocyanine as a Photosensitizing Agent in Cancer Photodynamic Therapy
Author(s) -
Bispo Mafalda,
Pereira Patrícia M. R.,
Setaro Francesca,
RodríguezMorgade M. Salomé,
Fernandes Rosa,
Torres Tomás,
Tomé João P. C.
Publication year - 2018
Publication title -
chempluschem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.801
H-Index - 61
ISSN - 2192-6506
DOI - 10.1002/cplu.201800370
Subject(s) - photodynamic therapy , phthalocyanine , chemistry , aqueous solution , galactose , solubility , micelle , silicon , photochemistry , combinatorial chemistry , nuclear chemistry , organic chemistry
Two protected galacto‐dendritic units have been axially coordinated to the central ion of a silicon(IV) phthalocyanine to afford SiPcPGal 4 containing four units of galactose per macrocycle. These biological moieties provided better solubility in aqueous medium and a sensitizer with higher absorption peaks at 680–690 nm. The photodynamic activity of SiPcPGal 4 was evaluated against UM‐UC‐3 human bladder cancer cell line and the results were compared with the activity of the reported SiPcPGal 2 and SiPc(OH) 2 . SiPcPGal 4 had a better uptake and it was a better toxicity inducer than SiPcPGal 2 and SiPc(OH) 2 owing to its four galactose units, protected by isopropylidene groups, which can act as targeted micelles.