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Probing the Entropic Effect in Molecular Noncovalent Interactions between Resin‐Bound Polybrominated Arenes and Small Substrates
Author(s) -
Yamamoto Masanori,
Obara Miyuki,
Ochi Keisuke,
Yamamoto Atsushi,
Takenaka Katsuhiko,
Tanaka Tsunehiro,
Sato Kazunori
Publication year - 2018
Publication title -
chempluschem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.801
H-Index - 61
ISSN - 2192-6506
DOI - 10.1002/cplu.201800304
Subject(s) - chemistry , non covalent interactions , acetonitrile , molecule , computational chemistry , methanol , hydrogen bond , organic chemistry
The associative interaction between resin‐bound polybrominated arenes and small molecules was analyzed by using various spectroscopic techniques as well as a synthetic molecular model to establish the thermodynamics. The binding in acetonitrile was three orders of magnitude stronger than that in methanol, partly owing to the tertiary conformational gating of the resin that controls the entropic terms. By using the entropic superiority, the associative binding of up to 3×10 4 m −1 is achieved with the non‐biological system. A modified Hill plot for the quantitative analysis of bindings was also devised, which enabled the interactions at the molecular level to be elucidated.