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Dynameric Frameworks with Aggregation‐Induced Emission for Selective Detection of Adenosine Triphosphate
Author(s) -
Zhang Yan,
Li Yuhao,
Su Chengyong,
Barboiu Mihail
Publication year - 2018
Publication title -
chempluschem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.801
H-Index - 61
ISSN - 2192-6506
DOI - 10.1002/cplu.201800173
Subject(s) - adenosine triphosphate , chemistry , guanosine triphosphate , guanosine , adenosine , aggregation induced emission , selectivity , imine , fluorescence , biophysics , combinatorial chemistry , nucleotide , biochemistry , catalysis , biology , quantum mechanics , gene , physics
Luminogenic materials with aggregation‐induced emission (AIE) have attracted considerable interest for applications. If these systems aggregate, the free rotation of their scaffold is restricted, and as a consequence the photoluminescence increases. Herein, the first experimental observation of a “dynameric effect” on AIE is described. A comparison is made of the AIE of molecular and dynameric sensors that exhibit non‐linear turn‐on switching of fluorescence upon their interaction with adenosine triphosphate (ATP). Confirmation was obtained from the enhanced ATP detection with multivalent dynameric networks compared with a molecular sensor. The dynamic, reversible behaviour of the imine linkages is critical to produce this enhancement, as a static, imine‐reduced, polymeric sensor showed decreased AIE activity. The dynameric frameworks showed selectivity for ATP over adenosine diphosphate, and adenosine monophosphate over guanosine triphosphate or cytidine triphosphate. Together, these results will accelerate the systematic discovery of efficient adaptive biomimetic sensors.