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Computer‐Aided Design and Synthesis of 1‐{4‐[(3,4‐Dihydroxybenzylidene)amino]phenyl}‐5‐oxopyrrolidine‐3‐carboxylic Acid as an Nrf2 Enhancer
Author(s) -
Kahremany Shirin,
Babaev Ilana,
Hasin Pinhas,
Tamir Tigist Y.,
BenZur Tali,
Cohen Guy,
Jiang Zhengyu,
Weintraub Sagiv,
Offen Daniel,
Rahimipour Shai,
Major M. Ben,
Senderowitz Hanoch,
Gruzman Arie
Publication year - 2018
Publication title -
chempluschem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.801
H-Index - 61
ISSN - 2192-6506
DOI - 10.1002/cplu.201800155
Subject(s) - oxidative stress , enhancer , translation (biology) , oxidative phosphorylation , antioxidant , chemistry , transduction (biophysics) , amino acid , combinatorial chemistry , biochemistry , computational biology , microbiology and biotechnology , stereochemistry , biology , gene , gene expression , messenger rna
Invited for this month's cover is Prof. Arie Gruzman (Bar‐Ilan University) and collaborators who have developed an Nrf2 enhancer. This compound activated the Nrf2 transduction pathway and because of this the translation of dozens of antioxidant cytoprotective proteins in a dose‐ and time‐dependent manner and protected PC‐12 cells against oxidative stress. Considering the imbalance between production and elimination of oxidative species involved in the pathophysiology of many human diseases, this compound is a promising starting point for the development of novel therapeutics for the treatment of oxidative‐stress‐related diseases. Read the full text of the article at 10.1002/cplu.201700539 .