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An H 2 S‐Sensing/CO‐Releasing Flavonol That Operates via Logic Gates
Author(s) -
Soboleva Tatiana,
Benninghoff Abby D.,
Berreau Lisa M.
Publication year - 2017
Publication title -
chempluschem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.801
H-Index - 61
ISSN - 2192-6506
DOI - 10.1002/cplu.201700524
Subject(s) - molecule , fluorescence , molecular switch , chemistry , nanotechnology , sequence (biology) , molecular probe , intracellular , logic gate , reciprocal , biophysics , computer science , materials science , biology , physics , biochemistry , gene , linguistics , philosophy , organic chemistry , quantum mechanics , algorithm
Signaling molecules, including H 2 S and CO, are involved in a complex interplay within cells to maintain cellular homeostasis. In order to investigate the intracellular interplay of different gasotransmitters, new molecular tools are needed that combine the sensing and release capabilities of different small molecules in a single, multifunctional, and highly regulated molecular platform. This report gives the first example of a combined H 2 S‐sensor/CO‐releasing molecule. This flavonol‐based molecular tool operates intracellularly via a highly regulated AND logic gated input–output sequence and provides fluorescent feedback for the H 2 S detection and CO release steps. This linear sequence can be combined with a fluorescent molecular sensor for CO detection via a third distinct emission. Overall, this is the first molecular framework that can combine the sensing of H 2 S with the controlled release of CO, two gaseous molecules that are known to exhibit reciprocal regulation and have overlapping targets in cellular environments.