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A Ferrocene–Tryptophan Conjugate: The Role of the Indolic Nitrogen in Supramolecular Assembly
Author(s) -
Falcone Natashya,
Basak Shibaji,
Dong Bin,
Syed Jebriel,
Ferranco Annaleizle,
Lough Alan,
She Zhe,
Kraatz HeinzBernhard
Publication year - 2017
Publication title -
chempluschem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.801
H-Index - 61
ISSN - 2192-6506
DOI - 10.1002/cplu.201700407
Subject(s) - conjugate , ferrocene , supramolecular chemistry , tryptophan , chemistry , nitrogen , combinatorial chemistry , supramolecular assembly , organic chemistry , nanotechnology , stereochemistry , electrochemistry , materials science , molecule , amino acid , biochemistry , electrode , mathematical analysis , mathematics
Bio‐organometallic ferrocene‐containing amino acids and peptides have been reported to form gels and are interesting to study due to their structural properties and applications for biological purposes. In this study, a ferrocene‐dicarboxylic acid derivative of the dipeptide tryptophan–tryptophan was investigated. The indolic nitrogen in the amino acid tryptophan is important for biological functions due to its role in hydrogen bonding. Here, intermolecular interactions with the indolic nitrogen allow this conjugate to self‐assemble into a fibrous supramolecular structure that forms a stable gel. Rheological analysis demonstrates the self‐healing nature of this gel. Interestingly, X‐ray analysis of this ferrocene–peptide conjugate reveals close contacts involving tryptophan, in particular the indole NH group in interactions with an adjacent neighboring molecule.