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Synthesis and Antibacterial Activity of Polymerizable Acryloyloxyalkyltriethyl Ammonium Salts
Author(s) -
Mancuso Raffaella,
Amuso Roberta,
Armentano Biagio,
Grasso Giuseppe,
Rago Vittoria,
Cappello Anna Rita,
Galiano Francesco,
Figoli Alberto,
De Luca Giorgio,
Hoinkis Jan,
Gabriele Bartolo
Publication year - 2017
Publication title -
chempluschem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.801
H-Index - 61
ISSN - 2192-6506
DOI - 10.1002/cplu.201700194
Subject(s) - ammonium , chemistry , antibacterial activity , combinatorial chemistry , organic chemistry , bacteria , genetics , biology
This study reports an efficient and practical synthetic approach for the synthesis of a particularly important class of polymerizable quaternary ammonium salts (PQASs), that is, acryloxyalkyltriethylammonium bromides (AATEABs), which may find application as antimicrobial coatings for commercial membranes with antifouling and anti‐biofouling properties, to be used for wastewater treatment. The synthetic method is based on a simple two‐step procedure from commercially available substrates, entirely carried out under air and without any need for chromatographic purification. All the newly synthesized AATEABs were tested for their antimicrobial activity, and the results showed that AATEABs bearing an alkyl chain of 11 and particularly 12 carbon atoms possessed significant activity against Gram positive bacteria and yeast strains.