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Benzodifuran Derivatives as Potential Antiproliferative Agents: Possible Correlation between Their Bioactivity and Aggregation Properties
Author(s) -
Musumeci Domenica,
Roviello Giovanni N.,
Rigione Giuseppina,
Capasso Domenica,
Di Gaetano Sonia,
Riccardi Claudia,
Roviello Valentina,
Montesarchio Daniela
Publication year - 2017
Publication title -
chempluschem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.801
H-Index - 61
ISSN - 2192-6506
DOI - 10.1002/cplu.201600547
Subject(s) - hela , thermogravimetric analysis , chemistry , dispersity , metal ions in aqueous solution , combinatorial chemistry , biological activity , molecule , metal , biochemistry , organic chemistry , cell , in vitro
To further explore the properties and bioactivity of benzodifurans, three compounds in this class were synthesised and characterised using spectroscopic and spectrometric techniques, as well as SEM and thermogravimetric analysis. The synthesised compounds showed interesting antiproliferative activity on different human cancer cells (HeLa, Hep‐G2, WM266), whereas no relevant cytotoxic effect was observed on healthy control cells. To study the possible mechanism of action of the benzodifurans, their ability to bind various model DNA systems, their aggregation properties, and their ability to bind biologically relevant metal ions was evaluated. The molecules were found to form monodisperse nanoaggregates stable at physiological temperature, which are likely related to the observed bioactivity.