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Choice of Capping Group in Tripeptide Hydrogels Influences Viability in the Three‐Dimensional Cell Culture of Tumor Spheroids
Author(s) -
Wojciechowski Jonathan P.,
Martin Adam D.,
Mason Alexander F.,
Fife Christopher M.,
Sagnella Sharon M.,
Kavallaris Maria,
Thordarson Pall
Publication year - 2017
Publication title -
chempluschem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.801
H-Index - 61
ISSN - 2192-6506
DOI - 10.1002/cplu.201600464
Subject(s) - moiety , self healing hydrogels , tripeptide , spheroid , viability assay , phenothiazine , chemistry , peptide , 3d cell culture , stereochemistry , combinatorial chemistry , biophysics , cell , polymer chemistry , biochemistry , in vitro , biology , pharmacology
Two peptide‐derived low‐molecular‐weight gelators bearing different capping groups, 9‐fluorenylmethyloxycarbonyl (Fmoc) and phenothiazine, were synthesized and their gel networks were characterized. The variation of the N‐terminal capping group affects the viability of these hydrogels as a three‐dimensional cell culture for multicellular tumor spheroids. These results indicate that the phenothiazine capping group is a more biocompatible alternative to the widely used Fmoc moiety.