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Molecular Self‐Assembly of Cyclic Dipeptide Derivatives and Their Applications
Author(s) -
Manchineella Shivaprasad,
Govindaraju T.
Publication year - 2017
Publication title -
chempluschem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.801
H-Index - 61
ISSN - 2192-6506
DOI - 10.1002/cplu.201600450
Subject(s) - dipeptide , intermolecular force , diketopiperazines , rigidity (electromagnetism) , structural rigidity , nanotechnology , hydrogen bond , self assembly , molecular engineering , molecular machine , molecular dynamics , materials science , chemistry , combinatorial chemistry , molecule , computational chemistry , organic chemistry , peptide , engineering , biochemistry , composite material , structural engineering
Cyclic dipeptides (CDPs) are heterocyclic 2,5‐diketopiperazines with exceptional structural rigidity, enzymatic stability, and biological activity, exhibiting a substantial tendency to take part in intermolecular interactions. Strong intermolecular interactions driven by unique hydrogen bonding patterns render CDPs with a high propensity to undergo molecular self‐assembly. In this Review, the aim is to provide a comprehensive summary of design strategies used to engineer the molecular self‐assembly of CDPs into functional nano‐ and micro‐architectures and molecular gels with potential applications in biomedical and materials engineering fields.